MEDIPLEX DIETARY SYSTEM WORKS BETTER THAN OTHER DIET PLANS
Context : We have compared popular diets, particularly those low in carbohydrates,
diet for weight loss to check the effectiveness of Mediplex System Vs other
Objective: To compare 5 weight-loss diets representing a spectrum of low to high
carbohydrate intake for effects on weight loss and related metabolic variables.
Design, Setting, and Participants
conducted twelve-month randomized trial conducted in the
Intervention Participants were randomly assigned to follow the Mediplex (77), Atkins (n = 77),
Zone (n = 79), LEARN (n = 79), or Ornish (n = 76)
diets and received weekly instruction for 2 months, then an additional 10-month
Main Outcome Measures The primary outcome was weight and inch loss at 12 months.
Secondary outcomes included lipid profile (low-density lipoprotein, high-density
lipoprotein, and non–high-density lipoprotein cholesterol, and triglyceride
levels), percentage of body fat, waist-hip ratio, fasting insulin and glucose
levels, and blood pressure. Outcomes were assessed at months 0, 2, 6, and 12.
Results Weight loss was greater for women in the Mediplex diet group compared with
the other diet groups at 12 months, and mean 12-month weight loss was
significantly different between the Atkins and Zone diets (P<.05).
Mean 12-month weight loss was as follows: Mediplex −9.7 kg (95% confidence
interval [CI], −11.3 to −7.1 kg),
Atkins, −4.7 kg (95% confidence interval [CI], −6.3 to
−3.1 kg), Zone, −1.6 kg (95% CI, −2.8 to −0.4 kg),
LEARN, −2.6 kg (−3.8 to −1.3 kg), and Ornish, −2.2 kg
(−3.6 to −0.8 kg). Weight loss was not statistically different among
the Zone, LEARN, and Ornish groups. At 12 months, secondary outcomes for the
Mediplex group were far better than the other diet groups.
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