Letrozole to Increase Height: Is it Safe ????
Experts have come up with a P450 aromatase inhibitor called letrozole to increase the height of young adults by delaying bone maturation which is escalated through the estrogen hormone.
Estrogen is responsible for regulating bone maturation and eventually causes the bones to fuse and initiates the growth process of a person thereby increasing his or her height. Studies reveal that letrozole inhibits the process of bone maturation and triggers a height increase without much effort.
A study conducted on young adults revealed a remarkable increase in height over a five-month period where children were treated with letrozole to reap the benefits of an additional height. It was proved that even through an extensive fitness and stretching regime such additional heights could not be achieved.
Related findings also support the view that an increase in final adult height can be achieved in young boys and adults who have open growth plates by hindering estrogen action.
Researchers therefore assert that pubertal growth rate can be blocked by preventing bone maturation and increasing height prospects through letrozole treatment.
The role of oestrogens in the closure of growth plates in both sexes is unequivocal. We postulated that inhibition of oestrogen synthesis in boys with delayed puberty would delay maturation of the growth plates and ultimately result in increased adult height.
We did a randomised, double-blind, placebo-controlled study in which we treated boys with constitutional delay of puberty with testosterone and placebo, or testosterone and letrozole. Boys who decided to wait for the spontaneous progression of puberty without medical intervention composed the untreated group.
Letrozole effectively inhibited oestrogen synthesis and delayed bone maturation. Progression of bone maturation was slower in the letrozole group than in the placebo group. In 18 months, bone age had advanced 1·1 (SD 0·8) years in the untreated group and 1·7 (0·9) years in the group treated with testosterone and placebo, but only 0·9 (0·6) years in the letrozole group (p=0·03 between the treatment groups). Predicted adult height did not change significantly in the untreated group and in the placebo group, whereas in the group treated with letrozole the increase was 5·1 (3·7) cm (p=0·004).
Our findings suggest that if oestrogen action is inhibited in growing adolescents, adult height will increase. This finding provides a rationale for studies that aim to delay bone maturation in several growth disorders.
The question mediplex team ask
A) Is it safe to give this medicine ? What would be long term consequences ?
B) This was given to boys whose puberty was delayed that means they had some medical problem whereas no where it is mentioned that we should give to every one even normal children. Further once your growth plates are fused we dont think this medicine is going to work at all.
All the best
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