Role of Epiphyseal plates in Height Increase


The epiphyseal plate (or epiphysial platephysis, or growth plate) is a hyaline cartilage plate in the metaphysis at each end of along bone. The plate is found in children and adolescents; in adults, who have stopped growing, the plate is replaced by an epiphyseal line.


Role in bone elongation

Endochondral ossification is responsible for the initial bone development from cartilage in utero and infants and the longitudinal growth of long bones in the epiphyseal plate. The plate's chondrocytes are under constant division by mitosis. These daughter cells stack facing the epiphysis while the older cells are pushed towards the diaphysis. As the older chondrocytes degenerate, osteoblasts ossify the remains to form new bone. In puberty increasing levels of estrogen, in both males and females, leads to increasedapoptosis of chondrocytes in the epiphyseal plate.[1] Depletion of chondrocytes due to apoptosis leads to less ossification and growth slows down and later stops when the entire cartilage have become replaced by bone, leaving only a thin epiphyseal scar which later disappears.[2] Once the adult stage is reached, the only way to manipulate height is modifying bone length via distraction osteogenesis.

Histological organization

The growth plate has a very specific morphology in having a zonal arrangement.

Epiphyseal plate zone (from epiphysis to diaphysis


Zone of reserve

Quiescent chondrocytes are found at the epiphyseal end

Zone of proliferation

Chondrocytes undergo rapid mitosis under influence of growth hormone

Zone of maturation and hypertrophy

Chondrocytes stop mitosis, and begin to hypertrophy by accumulating glycogen, lipids, and alkaline phosphatase

Zone of calcification

Chondrocytes undergo apoptosis. Cartilagenous matrix begins to calcify.

Zone of ossification

Osteoclasts and osteoblasts from the diaphyseal side break down the calcified cartilage and replace with mineralized bone tissue.


A mnemonic for remembering the names of the epiphyseal plate growth zones is " Real People Have Career Options," standing for: Resting zone, Proliferative zone, Hypertrophic cartilage zone, Calcified cartilage zone, Ossification zone. The growth plate is clinically relevant in that it is often the primary site for infection, metastasis, fractures and the effects of endocrine bone disorders.


Defects in the development and continued division of epiphyseal plates can lead to growth disorders. The most common defect is achondroplasia, where there is a defect in cartilage formation. Achondroplasia is the most common cause of dwarfism.

Salter–Harris fractures are fractures involving epiphyseal plates and hence tend to interfere with growth and height.

Osgood-Schlatter Disease results from stress on the Epiphyseal plate in the tibia, leading to excess bone growth and a painful lump at the knee.

Studies in animals

John Hunter studied growing chickens. He observed bones grew at the ends and thus demonstrated the existence of the epiphyseal plates. Hunter is considered the "father of the growth plate".[5]









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Mediplex Clinic® is proud to introduce a revolutionary height increase program that promise permanent height increase in children and adults even beyond 18 years. It challenges conventional wisdom about height increase and views stop of growth as a medical condition requiring medical attention. This program has been researched and scientific. It has been rigorously tested and proven on over 500 children in an in-house clinical trial.

Our Height Increase program is designed based upon scientific principles of increasing the stretching through highly effective yoga postures, correcting metabolic defects, correcting internal diseases and as well as giving well balanced nutritious diet.

Our Program consist of 4 primary components:

A) Height Increase Medicine:

We have discovered a herbal preparation called as Grow Plex. This medicine contains herbal and homeopathic components which remove metabolic blocks in the body stopping growth on individual. This is completely safe and without any side effects. This can be used alone or in combination with other medicines (Allopathic etc) and it has not shown any interaction with other medicines. Further, our panel of skilled and expert doctors handles slow growth cases associated with hormonal, hypo-thyroidism, , nutritional; problems etc. We have seen excellent results in these cases also.

B) Life Style Modification:

In this option we work on the root cause of slow growth such as eating habits, stress etc. A personal dietician devise a doable nutritious plan based upon your eating habits, tastes, body type and other preferences. 

C) Yoga and Physical Exercise:

Yoga is considered to be an ancient science for promotion of well being and healthy living. Our team of senior therapists has developed an advance program on simple yoga asana which for height increase for kids and adults.


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