Growing Tall Mechanisms: Insights
Many people want to understand the mechanism of growing tall. Now height
increase is traditionally occur at growth plates-epiphyseal and diaphyseal
fusion. If you consider cellular mechanisms chondrocytes and osteoblasts are
set of cells which influence height increase.
Growing Taller involves stem cell precursor cells differentiating into stem
cells which differentiate into chondrocytes. Proliferation of each of these
cells can occur dependent on telomere length and DNA Methylation status. Then
chondrocytes hypertrophy and then alkaline phosphatase and Collagen X is
involved when the chondrocytes undergo apoptosis and differentiate into
Now, in what part of that description did I mention growth plates? The key
factor to growing taller is the chondrocyte hypertrophy. Larger cells means
larger bone volume. Stem cells remain in the bone marrow post epiphyseal and
diaphyseal fusion. These stem cells can differentiate into chondrocytes and if
these chondrocytes undergo hypertrophy you will grow taller.
Stem cells can differentiate into chondrocytes based on hydrostatic pressure
and Type II Collagen. Hydrostatic Pressure can be generated after puberty by
lateral or vertical compression of the bone(lateral is better). Type II
Collagen is abundantly present in all bones.
There are tons of stem cells in the body as they are needed to form and repair
blood vessels. There are lots of stem cells in bone as well. If you activate
these stem cells and these stem cells differentiate into chondrocytes which
proceed to hypertrophy then you will grow taller.
The obstacle again is not growth plate fusion but rather the DNA Methylation
status or telomere length of the stem cell. Endochondral Ossification seems to
occur largely at a cellular level and not a larger growth plate level. Many of
the genes involved in Endochondral Ossification can be upregulated at any time
such as Sox9.
The other type of cell that can make you taller is osteoblasts. Osteoblasts
beneath the periosteum can easily make you taller such as the periosteum
covering the flat bone of the skull. However, there is no layer of periosteum
covering the ends of long bones(there may be patches but a detailed
histological exam would be required). However, you can still grow taller by
something called surface osteoblasts.
Stem cells can differentiate into osteoblasts within the bone including the
longitudinal ends of the bones(called the subchondral plate). Exactly what
factors determine whether stem cells differentiate into chondrocytes or
osteoblasts is unclear. It may depend on things such as the methylation status
of the stem cells. If osteoblasts deposit new bone on the longitudinal ends of
your bones then you will grow taller.
Epiphyseal fusion involves terminal differentiation of chondrocytes followed
by invasion of the hyaline cartilage growth plate line by bone. Epiphyseal
fusion in no way inhibits stem cells from differentiating into chondrocytes or
osteoblasts. In fact according to heterotopic ossification bone can be formed
anywhere in the body even outside the skeleton. There are also disorders
called chondrosarcoma and osteosarcoma that involve chondrogenic and
osteogenic differentiation after puberty.
Now you may think messing with telomeres is dangerous. However, cancer is
usually formed by Alternate Lengthening of Telomeres not by methods such as
increasing Telomerase levels. Just be sure to be taking anti-oxidants and DNA
protectors such as folic acid to prevent DNA damage.
You can also get new stem cells that haven't been methylated by sources such
as breast milk. If methylation status of stem cells prevents chondrogenic
differentiation then getting fresh stem cells may allow height growth to begin
So you see growing taller isn't about growth plate fusion, it's about cells.
Controlling the differentiation of those cells and increasing the
proliferation of those cells. Don't let growth plate fusion fuse your mind to
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